SroB RNA

sroB RNA
Predicted secondary structure and sequence conservation of sroB
Identifiers
Symbol sroB
Rfam RF00368
Other data
RNA type Gene; sRNA
Domain(s) Bacteria
SO 0000655

The sroB RNA (also known as MicM or rybC) is a non-coding RNA gene of 90 nucleotides in length. sroB is found in several Enterobacterial species but its function is unknown.[1][2] SroB is found in the intergenic region on the opposite strand to the ybaK and ybaP genes.[1] SroB is expressed in stationary phase.[1] Experiments have shown that SroB is a Hfq binding sRNA.[2] [3]

Further evidence has shown that SroB negatively regulates the outer membrane protein YbfM by sequestering the ribosome binding site of ybfM mRNA by an antisense interaction.[4] Furthermore, SroB itself appears to be the target of a non-coding transcript from the chBC intergenic region.[5] [6] [7]

References

  1. ^ a b c Vogel J, Bartels V, Tang TH, et al. (2003). "RNomics in Escherichia coli detects new sRNA species and indicates parallel transcriptional output in bacteria". Nucleic Acids Res. 31 (22): 6435–43. doi:10.1093/nar/gkg867. PMC 275561. PMID 14602901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=275561. 
  2. ^ a b Zhang A, Wassarman KM, Rosenow C, Tjaden BC, Storz G, Gottesman S (November 2003). "Global analysis of small RNA and mRNA targets of Hfq". Mol. Microbiol. 50 (4): 1111–24. doi:10.1046/j.1365-2958.2003.03734.x. PMID 14622403. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0950-382X&date=2003&volume=50&issue=4&spage=1111. 
  3. ^ Sittka A, Lucchini S, Papenfort K, et al. (2008). Burkholder, William F.. ed. "Deep sequencing analysis of small noncoding RNA and mRNA targets of the global post-transcriptional regulator, Hfq". PLoS Genet. 4 (8): e1000163. doi:10.1371/journal.pgen.1000163. PMC 2515195. PMID 18725932. http://dx.plos.org/10.1371/journal.pgen.1000163. 
  4. ^ Rasmussen AA, Johansen J, Nielsen JS, Overgaard M, Kallipolitis B, Valentin-Hansen P (April 2009). "A conserved small RNA promotes silencing of the outer membrane protein YbfM". Mol. Microbiol. 72 (3): 566–77. doi:10.1111/j.1365-2958.2009.06688.x. PMID 19400782. http://www3.interscience.wiley.com/resolve/doi/abs?DOI=10.1111/j.1365-2958.2009.06688.x. 
  5. ^ Overgaard M, Johansen J, Møller-Jensen J, Valentin-Hansen P (2009). "Switching off small RNA regulation with trap-mRNA.". Mol Microbiol 73 (5): 790–800. doi:10.1111/j.1365-2958.2009.06807.x. PMID 19682266. 
  6. ^ Vogel J (July 2009). "An RNA trap helps bacteria get the most out of chitosugars". Mol. Microbiol. 73 (5): 737–41. doi:10.1111/j.1365-2958.2009.06806.x. PMID 19659640. http://www3.interscience.wiley.com/resolve/doi/abs?DOI=10.1111/j.1365-2958.2009.06806.x. 
  7. ^ Figueroa-Bossi N, Valentini M, Malleret L, Fiorini F, Bossi L (2009). "Caught at its own game: regulatory small RNA inactivated by an inducible transcript mimicking its target.". Genes Dev 23 (17): 2004–15. doi:10.1101/gad.541609. PMC 2751969. PMID 19638370. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2751969. 

External links